diff --git a/sqlmodel/main.py b/sqlmodel/main.py
index 38c85915aa..9ca90a87af 100644
--- a/sqlmodel/main.py
+++ b/sqlmodel/main.py
@@ -52,7 +52,14 @@
 from sqlalchemy.orm.instrumentation import is_instrumented
 from sqlalchemy.sql.schema import MetaData
 from sqlalchemy.sql.sqltypes import LargeBinary, Time, Uuid
-from typing_extensions import Literal, TypeAlias, deprecated, get_origin
+from typing_extensions import (
+    Annotated,
+    Literal,
+    TypeAlias,
+    deprecated,
+    get_args,
+    get_origin,
+)
 
 from ._compat import (  # type: ignore[attr-defined]
     IS_PYDANTIC_V2,
@@ -473,6 +480,16 @@ def Relationship(
     return relationship_info
 
 
+def get_annotated_relationshipinfo(t: Any) -> Optional[RelationshipInfo]:
+    """Get the first RelationshipInfo from Annotated or None if not Annotated with RelationshipInfo."""
+    if get_origin(t) is not Annotated:
+        return None
+    for a in get_args(t):
+        if isinstance(a, RelationshipInfo):
+            return a
+    return None
+
+
 @__dataclass_transform__(kw_only_default=True, field_descriptors=(Field, FieldInfo))
 class SQLModelMetaclass(ModelMetaclass, DeclarativeMeta):
     __sqlmodel_relationships__: Dict[str, RelationshipInfo]
@@ -513,7 +530,12 @@ def __new__(
             else:
                 dict_for_pydantic[k] = v
         for k, v in original_annotations.items():
-            if k in relationships:
+            # check for `field: Annotated[Any, Relationship()]`
+            t = get_annotated_relationshipinfo(v)
+            if t:
+                relationships[k] = t
+                relationship_annotations[k] = get_args(v)[0]
+            elif k in relationships:
                 relationship_annotations[k] = v
             else:
                 pydantic_annotations[k] = v